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What is the best way to use NetBackup Appliance to backup large NAS system

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We are in the middle of a project to replace our current BackupExec 2012 with Data Domain 565 backup architecture with one of 3 possible solutions:

 

1. NetBackup 5230 Appliances (1x5230 with 76TB at primary DC and 2x5230 with 76TB each at secondary DC)

2. EMC Avamar/DD2500 (with NDMP Accelerator node and 1x90TB at primary DC and 1x135TB at secondary DC)

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